Investigation of the effect of perineural invasion on survival rates in rectal tumors.

Purpose: Colorectal cancers compose the third most common cancer group leading to death, with increasing rates in developed countries after lung and breast cancers. Rectal make up about 30% of all colorectal Although many factors affecting recurrence survival rectal have been identified, stage tumor is important prognostic factor. However, additional parameters that can be associated affect adjuvant treatment plan identified besides stage. Perineural invasion (PNI) one The aim this study investigate effects various histopathological factors, including PNI, on disease-free survival, overall patients who underwent surgery. Materials methods: clinical records diagnosed operated at Department General Surgery, Faculty Medicine, Pamukkale University between 2008-2014 were reviewed. To rates, presence serum CEA levels, cTNM stage, pT pN number metastatic LNs, budding status, grades, lymphocyte infiltration, desmoplasia evaluated patients. 
 Results: A total 124 included study. 42 (33.9%) had PNI while 82 (66.1%) did not PNI. Of 45 recurrence, 26 19 79 without 16 63 Similarly, was seen more frequently deaths related disease. 3-year average 55% 89%, respectively (p